Hesperadin |CAS:422513-13-1 Probechem Biochemicals

Chemical Structure : Hesperadin

CAS No.: 422513-13-1

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Hesperadin

货号: PC-42868Not For Human Use, Lab Use Only.

Hesperadin is a small molecule Aurora B inhibitor (IC50=250 nM) that perturbs mitosis and induces polyploidy, causes mammalian cells to enter anaphase in the presence of monooriented chromosomes.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

Hesperadin is a small molecule Aurora B inhibitor (IC50=250 nM) that perturbs mitosis and induces polyploidy, causes mammalian cells to enter anaphase in the presence of monooriented chromosomes.
Hesperadin inhibits histone H3 phosphorylation and causes midspindle defects, but does not inhibit APC and separase activation.
Hesperadin also markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1, and PHK in vitro.

物理化学性质&存储条件

分子量	516.6544
分子式	C29H32N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethanesulfonamide, N-[2,3-dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]-

参考文献

1. Hauf S, et al. J Cell Biol. 2003 Apr 28;161(2):281-94.

2. Sessa F, et al. Mol Cell. 2005 Apr 29;18(3):379-91.

3. Kapoor TM, et al. Science. 2006 Jan 20;311(5759):388-91.

4. Jetton N, et al. Mol Microbiol. 2009 Apr;72(2):442-58.

Hesperadin

生物&药学活性

物理化学性质&存储条件

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Hesperadin

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