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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Aurora Kinase-PHA-680626
PHA-680626

Chemical Structure : PHA-680626

CAS No.: 398493-74-8

PHA-680626 (PHA680626)

货号: PC-38795Not For Human Use, Lab Use Only.

PHA-680626 is a kinase inhibitor exhibiting strong inhibitory activity on both Bcr-Abl and Aurora kinases, also inhibits the formation of the Aurora-A/N-Myc complex.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PHA-680626 is a kinase inhibitor exhibiting strong inhibitory activity on both Bcr-Abl and Aurora kinases, also inhibits the formation of the Aurora-A/N-Myc complex.
    PHA-680626 demonstrated significant anti-proliferative and pro-apoptotic effects in human BCR-ABL positive cell lines and murine BaF3 cells ectopically expressing wt BCR-ABL or the Imatinib-resistant BCR-ABL mutants M351T, E255K and, T315I.
    PHA-680626 is an amphosteric inhibitor both in vitro and in MYCN overexpressing cell lines.

    物理化学性质&存储条件

    分子量 450.56
    分子式 C23H26N6O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4-(4-methylpiperazin-1-yl)-N-(5-(2-(thiophen-2-yl)acetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide

    参考文献

    1. Kothe M, et al. Biochemistry. 2007 May 22;46(20):5960-71.

    2. Gontarewicz A, et al. Leuk Res. 2008 Dec;32(12):1857-65.

    3. Dalila Boi, et al. Int J Mol Sci. 2021 Dec 4;22(23):13122.

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