PHA-680626 | Aurora Kinase inhibitor | Probechem Biochemicals

Chemical Structure : PHA-680626

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PHA-680626 (PHA680626)

货号: PC-38795Not For Human Use, Lab Use Only.

PHA-680626 is a kinase inhibitor exhibiting strong inhibitory activity on both Bcr-Abl and Aurora kinases, also inhibits the formation of the Aurora-A/N-Myc complex.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PHA-680626 is a kinase inhibitor exhibiting strong inhibitory activity on both Bcr-Abl and Aurora kinases, also inhibits the formation of the Aurora-A/N-Myc complex.
PHA-680626 demonstrated significant anti-proliferative and pro-apoptotic effects in human BCR-ABL positive cell lines and murine BaF3 cells ectopically expressing wt BCR-ABL or the Imatinib-resistant BCR-ABL mutants M351T, E255K and, T315I.
PHA-680626 is an amphosteric inhibitor both in vitro and in MYCN overexpressing cell lines.

物理化学性质&存储条件

分子量	450.56
分子式	C23H26N6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-methylpiperazin-1-yl)-N-(5-(2-(thiophen-2-yl)acetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide

参考文献

1. Kothe M, et al. Biochemistry. 2007 May 22;46(20):5960-71.

2. Gontarewicz A, et al. Leuk Res. 2008 Dec;32(12):1857-65.

3. Dalila Boi, et al. Int J Mol Sci. 2021 Dec 4;22(23):13122.

PHA-680626 (PHA680626)

生物&药学活性

物理化学性质&存储条件

参考文献

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PHA-680626 (PHA680626)

生物&药学活性

物理化学性质&存储条件

参考文献

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