F114 | Aurora/LIMK inhibitor | Probechem Biochemicals

Chemical Structure : F114

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F114 (Aurora/LIMK inhibitor)

货号: PC-73347Not For Human Use, Lab Use Only.

F114 is a novel, first-in-class, dual aurora and lim kinase (LIMK) inhibitor with IC50 of 72 nM and 137 nM against Aurora-A and Limk1, respectively, F114 inhibits GBM proliferation and invasion.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

F114 is a novel, first-in-class, dual Aurora and lim kinase (LIMK) inhibitor with IC50 of 72 nM and 137 nM against Aurora-A and Limk1, respectively, F114 inhibits GBM proliferation and invasion.

物理化学性质&存储条件

分子量	312.377
分子式	C16H20N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-isopropyl-2-((1-isopropyl-1H-pyrazol-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

参考文献

1. Matthew J Rybin, et al. Bioorg Med Chem Lett. 2022 Apr 1;61:128614.