CCT129202 |CAS:942947-93-5 Probechem Biochemicals

Chemical Structure : CCT129202

CAS No.: 942947-93-5

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CCT129202 (CCT-129202;CCT 129202)

货号: PC-42864Not For Human Use, Lab Use Only.

CCT129202 is a potent, selective, ATP-competitive pan-Aurora kinase inhibitor with IC50 of 42, 198 and 227 nM for Aurora A, Aurora B and Aurora C, respectively.

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10 mg	￥780	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

CCT129202 is a potent, selective, ATP-competitive pan-Aurora kinase inhibitor with IC50 of 42, 198 and 227 nM for Aurora A, Aurora B and Aurora C, respectively.
CCT129202 displays high selectivity for the Aurora kinases over a broad range of 13 other kinases.
CCT129202 inhibits proliferation in multiple cultured human tumor cell lines (GI50=0.08-1.7 uM), induces aberrant mitosis that leads to apoptosis.
CCT129202 reduces phosphorylation of histone H3, stabilizes p53, and inhibits growth of HCT116 human colon cancer xenografts in athymic mice.

物理化学性质&存储条件

分子量	497.0156
分子式	C23H25ClN8OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Piperazineacetamide, 4-[6-chloro-2-[4-(dimethylamino)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]-N-2-thiazolyl-

参考文献

1. Chan F, et al. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3147-57.

2. Cheng C, et al. Mol Pharm. 2012 Jul 2;9(7):1971-82.

3. Tobío A, et al. Antiinflamm Antiallergy Agents Med Chem.

CCT129202 (CCT-129202;CCT 129202)

生物&药学活性

物理化学性质&存储条件

参考文献

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CCT129202 (CCT-129202;CCT 129202)

生物&药学活性

物理化学性质&存储条件

参考文献

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