AMG-900 |CAS:945595-80-2 Probechem Biochemicals

Chemical Structure : AMG-900

CAS No.: 945595-80-2

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AMG-900 (AMG 900;AMG900)

货号: PC-43432Not For Human Use, Lab Use Only.

AMG-900 (AMG900) is a potent, highly selective, orally bioavailable pan-Aurora kinase inhibitor with IC50 of 5, 4 and 1 nM for Aurora A, B and C, respectively.

规格	价格	库存
10 mg	￥1380	In stock
25 mg	￥2180	In stock
50 mg	￥3480	In stock
100 mg		Get quote

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生物&药学活性

AMG-900 (AMG900) is a potent, highly selective, orally bioavailable pan-Aurora kinase inhibitor with IC50 of 5, 4 and 1 nM for Aurora A, B and C, respectively.
AMG-900 displays excellent specificity in a panel of 26 kinases with exception of p38α and TYK2 (IC50=53 and 220 nM), also exhibits high affinity (Kd< 50 nM) with DDR1, DDR2, and LTK receptor tyrosine kinases.
AMG-900 blocks the proliferation of multiple human tumor cell lines including cell lines resistant to paclitaxel, AZD1152, MK-0457, and PHA-739358 with IC50 of 0.7-5.3 nM.
AMG-900 blocks the phosphorylation of histone H3 in a dose-dependent manner and significantly inhibits the growth of HCT116 tumor xenografts.

物理化学性质&存储条件

分子量	503.58
分子式	C28H21N7OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Phthalazinamine, N-[4-[[3-(2-amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-

参考文献

1. Geuns-Meyer S, et al. J Med Chem. 2015 Jul 9;58(13):5189-207.

2. Juan G, et al. J Transl Med. 2014 Nov 4;12:307.

3. Paller CJ, et al. Cancer Med. 2014 Oct;3(5):1322-35.

4. Payton M, et al. Cancer Res. 2010 Dec 1;70(23):9846-54.

AMG-900 (AMG 900;AMG900)

生物&药学活性

物理化学性质&存储条件

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AMG-900 (AMG 900;AMG900)

生物&药学活性

物理化学性质&存储条件

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