欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Aurora Kinase-TAS-119
TAS-119

Chemical Structure : TAS-119

CAS No.: 1453099-83-6

加入收藏

TAS-119 (TAS119)

货号: PC-72439Not For Human Use, Lab Use Only.

TAS-119 (TAS119) is a potent, selective, orally active inhibitor of Aurora A with IC50 of 1 nM.

规格 价格 库存 数量
5 mg ￥1980 In stock
10 mg ￥3280 In stock
25 mg ￥5480 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TAS-119 (TAS119) is a potent, selective, orally active inhibitor of Aurora A with IC50 of 1 nM.
TAS-119 displayed high target selectivity among 301 protein kinases, including Aurora B (IC50=95 nM) and Aurora C (IC50=35 nM).
TAS-119 dose dependently enhanced cell growth inhibition by paclitaxel, docetaxel, and cabazitaxel, also potentiated another microtubule stabilizer Epothilone B.
TAS-119 enhanced the antiproliferative effect of paclitaxel in different cell lines, including paclitaxel-resistant cells.
TAS-119 did neither induce mitosis and nor enhance the antiproliferative effect of paclitaxel in normal lung fibroblast cells.
TAS-119 enhanced the antitumor efficacy of paclitaxel and docetaxel in a nude mice NCI-H460 xenograft model, did not exaggerate paclitaxel-induced neutropenia and neurotoxicity.

物理化学性质&存储条件

分子量 506.359
分子式 C23H22Cl2FN5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-

参考文献

1. Sootome H, et al. Mol Cancer Ther. 2020 Oct;19(10):1981-1991.

2. Robbrecht DGJ, et al. Br J Cancer. 2021 Jan;124(2):391-398.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: