| Cat. No. |
Product Name |
Information |
| PC-43158 |
10058-F4
c-Myc inhibitor
|
10058-F4 is a specific c-Myc inhibitor that disrupts the association between the c-Myc and Max, inhibits HL60 cell growth with IC50 of 51 uM. |
| PC-61770 |
BTYNB
IMP1/c-Myc inhibitor
|
BTYNB is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA with IC50 of 5 uM. |
| PC-61359 |
IRES-C11
c-Myc inhibitor
|
IRES-C11 is a spectfic c-Myc IRES (internal ribosome entry site) function inhibitor that prevents binding of hnRNP A1 to the Myc IRES and specifically inhibits Myc IRES activity in MM cells. |
| PC-61358 |
IRES-J007
IRES inhibitor
|
IRES-J007 is an improved IRES inhibitor that blocks IRES-hnRNP A1 binding, binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11). |
| PC-70283 |
Stauprimide
NME2 inhibitor, Myc inhibitor
|
Stauprimide (N-Benzoyl-7-oxo Staurosporine) is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transcription. |
| PC-60543 |
CBL0137
FACT inhibitor
|
CBL0137 (Curaxin CBL0137) is a histone chaperone FACT (facilitates chromatin transcription) and MYC signal inhibitor that markedly reduced tumor initiation and progression in vivo. |
| PC-60542 |
CMLD010509
|
CMLD010509 (SDS-1-021) is a rocaglate (flavagline) derivative that acts a highly specific inhibitor of the oncogenic translation program supporting MM, including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1. |
| PC-60241 |
sAJM-589
c-Myc inhibitor
|
sAJM-589 (sAJM589) is a novel, potent small molecule Myc inhibitor that disrupts the Myc-Max leucine-zipper heterodimer with IC50 of 1.8 uM. |
| PC-45695 |
KJ-Pyr-9
Myc inhibitor
|
KJ-Pyr-9 is a specific small-molecule inhibitor of MYC, inhibits MYC-MAX interaction, directly binds to MYC (Kd=6.5 nM) as well as to the MYC-MAX heterodimer (Kd=13.4 nM), interferes with its transcriptional and oncogenic activities.
|
| PC-42299 |
10074-G5
c-Myc inhibitor
|
10074-G5 is a small molecules that disrupts c-Myc-Max heterodimerization, binds to and distorts the bHLH-ZIP domain of c-Myc. |
| PC-24270 |
MI202
MYCN expression inhibitor
|
MI202 is a potent inhibitor of MYCN expression, inhibits both MYCN promoter activity (IC50=2.21 μM) and endogenous MYCN expression (IC50=1.07 μM) in JHH7 cells, through ACOT2-mediated signaling pathways. |
| PC-24225 |
MY05
c-Myc inhibitor
|
MY05 is a specific small molecule inhibitor of c-MYC, disrupts MYC-MAX interaction, induces reduced levels of active MYC. |
