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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-c-Myc-CBL0137
CBL0137

Chemical Structure : CBL0137

CAS No.: 1197996-80-7

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CBL0137 (CBL-0137, Curaxin CBL0137, CBLC 137)

货号: PC-60543Not For Human Use, Lab Use Only.

CBL0137 (Curaxin CBL0137) is a histone chaperone FACT (facilitates chromatin transcription) and MYC signal inhibitor that markedly reduced tumor initiation and progression in vivo.

规格 价格 库存 数量
5 mg ￥1180 In stock
10 mg ￥1880 In stock
25 mg ￥2980 In stock
50 mg ￥4580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CBL0137 (Curaxin CBL0137) is a histone chaperone FACT (facilitates chromatin transcription) and MYC signal inhibitor that markedly reduced tumor initiation and progression in vivo.
CBL0137 simultaneously activates p53 and inhibits NF-κB without causing detectable genotoxicity, causes phosphorylation of p53 Ser(392) by CK2 and inhibition of NF-κB-dependent transcription in neuroblastoma cells; .
CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer.

物理化学性质&存储条件

分子量 336.435
分子式 C21H24N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,1'-(9-(2-(isopropylamino)ethyl)-9H-carbazole-3,6-diyl)bis(ethan-1-one)

参考文献

1. Carter DR, et al. Sci Transl Med. 2015 Nov 4;7(312):312ra176.

2. Gasparian AV, et al. Sci Transl Med. 2011 Aug 10;3(95):95ra74.

3. Burkhart C, et al. Oncotarget. 2014 Nov 30;5(22):11038-53.

4. Barone TA, et al. Neuro Oncol. 2017 Feb 1;19(2):186-196.

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