MI202 | MYCN expression inhibitor | Probechem Biochemicals

Chemical Structure : MI202

CAS No.: 383135-58-8

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MI202 (MI-202)

货号: PC-24270Not For Human Use, Lab Use Only.

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10 mg	￥2480	In stock
25 mg	￥4280	In stock
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100 mg		Get quote

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生物&药学活性

MI202 is a potent inhibitor of MYCN expression, inhibits both MYCN promoter activity (IC50=2.21 μM) and endogenous MYCN expression (IC50=1.07 μM) in JHH7 cells, through ACOT2-mediated signaling pathways.
MI202 also suppressed MYCN protein expression in a time- and dose-dependent manner.
MI202 also reduced cell viability in JHH7 cells, both in monolayer (IC50 = 2.46 μM) and spheroid (IC50 = 1.55 μM) cultures, while no effects were observed in Hc cells (IC50 > 10 μM, respectively).
MI202 suppressed the expression of the cell cycle regulator cyclin B1 and upregulated the expression of the cyclin-dependent kinase inhibitor p15Ink4b in JHH7 cells.
MI202 induced apoptosis in JHH7 cells in a time- and dose-dependent manner.
MI202 significantly downregulated ACOT2 expression in JHH7 cells.

物理化学性质&存储条件

分子量	228.27
分子式	C12H8N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-benzothiazol-2-yl-1h-pyrrole-2-carbaldehyde

参考文献

1. Xu Y, et al. Front Oncol. 2025 Feb 14;15:1486671.

MI202 (MI-202)

生物&药学活性

物理化学性质&存储条件

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MI202 (MI-202)

生物&药学活性

物理化学性质&存储条件

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