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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-c-Myc-CMLD010509
CMLD010509

Chemical Structure : CMLD010509

CAS No.: 256497-58-2

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CMLD010509 (CMLD 010509;SDS-1-021)

货号: PC-60542Not For Human Use, Lab Use Only.

CMLD010509 (SDS-1-021) is a rocaglate (flavagline) derivative that acts a highly specific inhibitor of the oncogenic translation program supporting MM, including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CMLD010509 (SDS-1-021) is a rocaglate (flavagline) derivative that acts a highly specific inhibitor of the oncogenic translation program supporting MM, including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1.
    CMLD010509 induces apoptosis and inhibits the heat shock response in MM cells (IC50=10 nM).
    CMLD010509 is a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism and is highly effective in vivo in several mouse models.

    物理化学性质&存储条件

    分子量 556.409
    分子式 C27H26BrNO7
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R,2R,3S,3aR,8bS)-3a-(4-bromophenyl)-1,8b-dihydroxy-N,6,8-trimethoxy-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxamide

    参考文献

    1. Manier S, et al. Sci Transl Med. 2017 May 10;9(389). pii: eaal2668.

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