IRES-C11 | c-Myc IRES inhibitor | Probechem Biochemicals

Chemical Structure : IRES-C11

CAS No.: 342416-30-2

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IRES-C11 (IRES inhibitor C11)

货号: PC-61359Not For Human Use, Lab Use Only.

IRES-C11 is a spectfic c-Myc IRES (internal ribosome entry site) function inhibitor that prevents binding of hnRNP A1 to the Myc IRES and specifically inhibits Myc IRES activity in MM cells.

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10 mg	￥3980	In stock
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生物&药学活性

IRES-C11 is a spectfic c-Myc IRES (internal ribosome entry site) function inhibitor that prevents binding of hnRNP A1 to the Myc IRES and specifically inhibits Myc IRES activity in MM cells.
IRES-C11 shows no effect on BAG-1, XIAP and p53 IRESes, and has no significant effect on myc translation.
IRES-C11 significantly inhibits myc expression when combined with ER stress inducers, especially bortezomib.
IRES-C11 shows synergistic anti-MM cytotoxicity combined with ER stress inducers.
IRES-C11 also blocks cyclin D1 IRES-dependent initiation and demonstrates synergistic anti-GBM properties combined with PP242.

物理化学性质&存储条件

分子量	316.134
分子式	C13H11Cl2NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,4-dichloro-1-(2,4-dimethoxybenzyl)-1H-pyrrole-2,5-dione

参考文献

1. Shi Y, et al. Oncogene. 2016 Feb 25;35(8):1015-24.

2. Holmes B, et al. J Biol Chem. 2016 Jul 1;291(27):14146-59.

IRES-C11 (IRES inhibitor C11)

生物&药学活性

物理化学性质&存储条件

参考文献

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IRES-C11 (IRES inhibitor C11)

生物&药学活性

物理化学性质&存储条件

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