sAJM-589 |CAS:2089-82-9 Probechem Biochemicals

Chemical Structure : sAJM-589

CAS No.: 2089-82-9

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sAJM-589 (sAJM589)

货号: PC-60241Not For Human Use, Lab Use Only.

sAJM-589 (sAJM589) is a novel, potent small molecule Myc inhibitor that disrupts the Myc-Max leucine-zipper heterodimer with IC50 of 1.8 uM.

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25 mg	￥1380	In stock
50 mg	￥2280	In stock
100 mg	￥3980	In stock
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1 g		Get quote

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生物&药学活性

sAJM-589 (sAJM589) is a novel, potent small molecule Myc inhibitor that disrupts the Myc-Max leucine-zipper heterodimer with IC50 of 1.8 uM.
sAJM-589 preferentially inhibits transcription of MYC target genes in P493-6 cell.
sAJM-589 suppresses cellular proliferation in diverse MYC-dependent cancer cell lines, including P493-6, Ramos, HL-60 and KG1a (IC50=0.8-2 uM).
sAJM-589 reduces Myc protein levels in these cells, possibly by promoting ubiquitination and degradation of Myc protein.

物理化学性质&存储条件

分子量	246.269
分子式	C16H10N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzo[a]phenazin-5-ol

参考文献

1. Choi SH, et al. ACS Chem Biol. 2017 Oct 4. doi: 10.1021/acschembio.7b00799.

sAJM-589 (sAJM589)

生物&药学活性

物理化学性质&存储条件

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sAJM-589 (sAJM589)

生物&药学活性

物理化学性质&存储条件

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