IRES-J007 |CAS:155514-72-0 Probechem Biochemicals

Chemical Structure : IRES-J007

CAS No.: 155514-72-0

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IRES-J007 (IRESJ007; IRES J007)

货号: PC-61358Not For Human Use, Lab Use Only.

IRES-J007 is an improved IRES inhibitor that blocks IRES-hnRNP A1 binding, binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11).

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5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

IRES-J007 is an improved IRES inhibitor that blocks IRES-hnRNP A1 binding, binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11).
IRES-J007 significantly reduces tumor growth of GBM xenografts in mice.
IRES-J007 markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242.

物理化学性质&存储条件

分子量	297.31
分子式	C17H15NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2,4-Dimethoxyphenyl)methyl)isoindoline-1,3-dione

参考文献

1. Holmes B, et al. J Biol Chem. 2016 Jul 1;291(27):14146-59.

IRES-J007 (IRESJ007; IRES J007)

生物&药学活性

物理化学性质&存储条件

参考文献

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IRES-J007 (IRESJ007; IRES J007)

生物&药学活性

物理化学性质&存储条件

参考文献

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