10058-F4 | c-Myc inhibitor | Probechem Biochemicals

Chemical Structure : 10058-F4

CAS No.: 403811-55-2

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10058-F4 (10058F4)

货号: PC-43158Not For Human Use, Lab Use Only.

10058-F4 is a specific c-Myc inhibitor that disrupts the association between the c-Myc and Max, inhibits HL60 cell growth with IC50 of 51 uM.

规格	价格	库存
25 mg	￥980	In stock
50 mg	￥1680	In stock
100 mg	￥2980	In stock
200 mg		Get quote

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生物&药学活性

10058-F4 is a specific c-Myc inhibitor that disrupts the association between the c-Myc and Max, inhibits HL60 cell growth with IC50 of 51 uM.
10058-F4 arrests AML cells at G0/G1 phase, downregulates c-Myc expression and upregulates CDK inhibitors p21 and p27.
10058-F4 induces apoptosis through activation of mitochondrial pathway shown by downregulation of Bcl-2, upregulation of Bax, release of cytoplasmic cytochrome C, and cleavage of caspase 3, 7, and 9.
10058-F4 also induces myeloid differentiation.

物理化学性质&存储条件

分子量	249.3518
分子式	C12H11NOS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 41 mg/mL
Chemical Name/SMILES	4-Thiazolidinone, 5-[(4-ethylphenyl)methylene]-2-thioxo-

参考文献

1. Huang MJ, et al. Exp Hematol. 2006 Nov;34(11):1480-9.

2. Lin CP, et al. Anticancer Drugs. 2007 Feb;18(2):161-70.

3. Wang H, et al. Mol Cancer Ther. 2007 Sep;6(9):2399-408.

4. Guo J, et al. Cancer Chemother Pharmacol. 2009 Mar;63(4):615-25.

10058-F4 (10058F4)

生物&药学活性

物理化学性质&存储条件

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10058-F4 (10058F4)

生物&药学活性

物理化学性质&存储条件

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