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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-c-Myc-Stauprimide
Stauprimide

Chemical Structure : Stauprimide

CAS No.: 154589-96-5‎

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Stauprimide (N-Benzoyl-7-oxo Staurosporine)

货号: PC-70283Not For Human Use, Lab Use Only.

Stauprimide (N-Benzoyl-7-oxo Staurosporine) is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transcription.

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5 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Stauprimide (N-Benzoyl-7-oxo Staurosporine) is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transcription.
Stauprimide increases the efficiency of mouse and human embryonic stem cell differentiation in conjunction with lineage specification cues with EC50 of 0.3 uM.

物理化学性质&存储条件

分子量 584.6
分子式 C35H28N4O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((5R,7R,8R,9S)-8-methoxy-9-methyl-14,16-dioxo-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide

参考文献

1. Bouvard C, et al. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3497-3502.

2. Zhu S, et al. Cell Stem Cell. 2009 May 8;4(5):416-26.

3. Tahamtani Y, et al. Stem Cells Dev. 2013 May 1;22(9):1419-32.

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