| Cat. No. |
Product Name |
Information |
| PC-38395 |
Gemnelatinib
c-Met inhibitor
|
Gemnelatinib (GST-HG161) is a potent and highly selective, orally bioavailable c-Met inhibitor, displays significant antitumor activity in preclinical models, has the potential to be effective in HCC with active c-Met signaling. |
| PC-38394 |
Fosgonimeton
HGF/MET modulator
|
Fosgonimeton (ATH-1017, ATH-1001 prodrug) is a highly specific, small-molecule positive modulator of the HGF/MET neurotrophic system, is a prodrug that rapidly converts into the active metabolite ATH-1001 in plasma. |
| PC-36035 |
AMG-458
c-Met inhibitor
|
AMG-458 (AMG458) is a potent, selective, orally bioavailable c-Met inhibitor with Ki of 1.2 nM (human c-Met). |
| PC-35732 |
PLB-1001
MET inhibitor
|
PLB-1001 (Bozitinib, PLB1001, CBI-3103, CBT-101) is a potent, highly selective, ATP-competitive, BBB-permeable MET kinase inhibitor, potently inhibits MET activity by 95.1% at 2 uM. |
| PC-43511 |
Capmatinib
c-MET inhibitor
|
Capmatinib (INCB-28060, INC-280) is a highly potent, selective, ATP competitive inhibitor of c-MET kinase with IC50 of 0.13 nM. |
| PC-43478 |
MK-8033 hydrochloride
|
MK-8033 is a potent, specific, dual c-Met/Ron kinases inhibitor with IC50 of 1/7 nM, also potently inhibits oncogenic c-Met activation loop mutants Y1230C, Y1230H and Y1235D with IC50 of 0.6-1.2 nM. |
| PC-43477 |
MK-8033
c-Met/Ron inhibitor
|
MK-8033 is a potent, specific, dual c-Met/Ron kinases inhibitor with IC50 of 1/7 nM, also potently inhibits oncogenic c-Met activation loop mutants Y1230C, Y1230H and Y1235D with IC50 of 0.6-1.2 nM. |
| PC-63402 |
JNJ-38877618
c-Met inhibitor
|
JNJ-38877618 (OMO-1) is a novel potent, highly selective, orally bioavailable c-Met tyrosine kinase inhibitor with Kd of 1.2, 2.1 and 21 nM for WT, M1250T and Y1235D mutants MET, respectively. |
| PC-43372 |
E-7050
c-Met/VEGFR-2 inhibitor
|
E-7050 (Golvatinib) is a potent, dual c-Met and VEGFR-2 tyrosine kinase inhibitor with IC50 of 14 and 16 nM (kinase phosphorylation inhibition). |
| PC-42888 |
BMS 777607
c-Met inhibitor
|
BMS 777607 (ASLAN002) is a potent, selective, orally efficacious inhibitor of Met kinase with IC50 of 3.9 nM, also potently inhibits Ron, Axl, Tyro-3 and Mer (IC50<15 nM), 40-fold selectivity over Lck, VEGFR-2 and TrkA/B. |
| PC-42849 |
AMG-208
c-Met inhibitor
|
AMG-208 is a potent, small-molecule c-Met inhibitor with IC50 of 5.2 nM against wt MET kinase, also inhibits VEGFR2 with IC50 of 112 nM. |
| PC-42835 |
SGX-523
c-Met inhibitor
|
SGX-523 (SGX523) is a potent, selective ATP-competitive inhibitor of MET receptor tyrosine kinase with IC50 of 4 nM, does not inhibit RON and a panel of kinases. |
