LCRF-0004 | Ron kinase inhibitor | Probechem Biochemicals

Chemical Structure : LCRF-0004

加入收藏

LCRF-0004 (LCRF0004)

货号: PC-49516Not For Human Use, Lab Use Only.

LCRF-0004 is a potent and selective RON receptor tyrosine kinase inhibitor with IC50 of 50 nM (ELISA), weakly inhibits c-Met with IC50 of 150 nM and does not inhibit VEGFR2.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

LCRF-0004 is a potent and selective RON receptor tyrosine kinase inhibitor with IC50 of 50 nM (ELISA), weakly inhibits c-Met with IC50 of 150 nM and does not inhibit VEGFR2.
LCRF-0004 potently inhibited RON phosphorylation in cancer cells with IC50 of 30-40 nM, potently inhibited cellular proliferation in the HCT116 lung cancer cells.
LCRF-0004 displayed weak inhibition of c-Met phosphorylation in the MKN-45 gastric carcinoma cell line which over-expresses c-Met, as well as c-Met-dependent cell migration and scattering mediated by HGF.

物理化学性质&存储条件

分子量	578.55
分子式	C28H18F4N6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-fluoro-4-((2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide

参考文献

1. Raeppel SL, et al. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2527-31.

LCRF-0004 (LCRF0004)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

LCRF-0004 (LCRF0004)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.