| Cat. No. |
Product Name |
Information |
| PC-45848 |
MK-2461
c-Met inhibitor
|
MK-2461 is a potent multitargeted kinase inhibitor that preferentially inhibits c-Met with IC50 of 2.5 nM, with similar potencies for Ron and Flt1 (IC50=7 and 10 nM, respectively). |
| PC-42618 |
BMS-794833
Met/VEGFR2 inhibitor
|
BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50 of 1.7 nM/15 nM. |
| PC-45530 |
AMG-337
c-Met inhibitor
|
AMG-337 is a potent and selective inhibitor of MET with biochemical IC50 of 1 nM. |
| PC-23261 |
Dihexa
c-Met activator
|
Dihexa (PNB-0408, Hexanoyl-Tyr-Ile-Ahx-NH2) is an oligopeptide drug, orally active and blood-brain barrier-permeable angiotensin IV analog, binds to hepatocyte growth factor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor c-Met. |
| PC-22805 |
MET inhibitor 13
MET inhibitor
|
MET inhibitor 13 is a potent, selective and mutant-active MET kinase inhibitor with IC50 of 6/6 nM for D1228N/exon Δ14 enzyme, and 90/15/5 nM for F1200I/L1995 V/Y1230H mutants respectively. |
| PC-21442 |
WM-S1-030
Ron kinase inhibitor
|
WM-S1-030 is a highly potent, specific inhibitor of recepteur d'origine nantais (RON kinase, MST1R) with IC50 of 0.39 nM in in vitro enzyme activity. |
| PC-63568 |
BMS-817378
|
BMS-817378 is a prodrug of the dual Met/VEGFR-2 inhibitor BMS-794833.. |
| PC-42833 |
PF-04217903 methanesulfonate
|
PF-04217903 is a potent, selective, ATP-competitive c-Met kinase inhibitor with Ki of 4.8 nM, inhibits HGF-stimulated tyrosine phosphorylation of wild type c-Met with IC50 of 7.3 nM in cell-based assays. |
