MET inhibitor 13

Chemical Structure : MET inhibitor 13

加入收藏

货号: PC-22805Not For Human Use, Lab Use Only.

MET inhibitor 13 is a potent, selective and mutant-active MET kinase inhibitor with IC50 of 6/6 nM for D1228N/exon Δ14 enzyme, and 90/15/5 nM for F1200I/L1995 V/Y1230H mutants respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MET inhibitor 13 is a potent, selective and mutant-active MET kinase inhibitor with IC50 of 6/6 nM for D1228N/exon Δ14 enzyme, and 90/15/5 nM for F1200I/L1995 V/Y1230H mutants respectively.
MET inhibitor 13 displayed inhibition of only 5 kinases below 50% POC at 1 mM ATP against a panel of 396 kinases.
MET inhibitor 13 (30 mg/kg BID, oral) demonstrated antitumor activity in the subcutaneous Hs746T MET exon 14/MET amplified xenograft model.

物理化学性质&存储条件

分子量	612.58
分子式	C30H23F3N10O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2,5-Difluoro-4-((trans-3-(1-methyl-1H-pyrazol-3-yl)cyclobutyl)(pyrazolo[1,5-a]pyrazin-4-yl)amino)phenyl)-2-(5-fluoropyridin-2-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide

参考文献

1. Bumpers QA, et al. J Med Chem. 2024 Aug 1. doi: 10.1021/acs.jmedchem.4c01232.

MET inhibitor 13

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

MET inhibitor 13

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.