Capmatinib (INCB-28060, INC-280) | c-MET inhibitor | Probechem Biochemicals

Chemical Structure : Capmatinib

CAS No.: 1029712-80-8

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Capmatinib (INCB28060, INCB-28060, INC-280, INC280)

货号: PC-43511Not For Human Use, Lab Use Only.

Capmatinib (INCB-28060, INC-280) is a highly potent, selective, ATP competitive inhibitor of c-MET kinase with IC50 of 0.13 nM.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1180	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
250 mg		Get quote

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生物&药学活性

Capmatinib (INCB-28060, INC-280) is a highly potent, selective, ATP competitive inhibitor of c-MET kinase with IC50 of 0.13 nM.
Capmatinib (INCB-28060, INC-280) displays no activity against RONβ, EGFR and HER-3.
Capmatinib (INCB-28060, INC-280) inhibits c-MET phosphorylation (IC50=1 nM) in SNU-5 human gastric cancer cell line, is slightly more potent in H596 and H1437 lung cancer cell lines that express mutant c-MET due to an exon 14 deletion and a R988C mutation.
Capmatinib (INCB-28060, INC-280) inhibits c-MET phosphorylation and tumor growth in c-MET-driven mouse tumor models.

物理化学性质&存储条件

分子量	412.42
分子式	C23H17FN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 12.66 mg/mL
Chemical Name/SMILES	Benzamide, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-

参考文献

1. Liu X, et al. Clin Cancer Res. 2011 Nov 15;17(22):7127-38.

2. Brandes F, et al. BMC Cancer. 2015 Feb 19;15:71.

3. Moran-Jones K, et al. Sci Rep. 2015 Jul 3;5:11749.

Capmatinib (INCB28060, INCB-28060, INC-280, INC280)

生物&药学活性

物理化学性质&存储条件

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Capmatinib (INCB28060, INCB-28060, INC-280, INC280)

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