Dalmelitinib

Chemical Structure : Dalmelitinib

CAS No.: 1637658-98-0

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货号: PC-49132Not For Human Use, Lab Use Only.

Dalmelitinib is a potent, selective c-Met tyrosine kinase inhibitor with IC50 of 0.7 nM, inhibits cell growth of gastric cells SNU5 with IC50 of 2.0 nM, binds to the ATP-binding region of c-MET kinase.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1580	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

Dalmelitinib is a potent, selective c-Met tyrosine kinase inhibitor with IC50 of 0.7 nM, inhibits cell growth of gastric cells SNU5 with IC50 of 2.0 nM, binds to the ATP-binding region of c-MET kinase.
Dalmelitinib has a better inhibiting activity than SGX-523 in a dosedependent manner against different human tumor cell lines comprising human gastric (MKN-45) and human non-small cell lung (NCI-H1993).
Dalmelitinib (10, 30, 60 mg/kg) significantly inhibited the tumor (MKN-45) growth in nude mice and the inhibitory rates were 29.5%, 34.2%, and 61.4%, respectively.

物理化学性质&存储条件

分子量	461.475
分子式	C22H16FN7O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-((8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)thio)-4-methyl-2H-[1,4]oxazino[3,2-c]quinolin-3(4H)-one

参考文献

1. Patent CN108623619 A 2018-10-09 .

2. Junjun Zhao, et al. Bioorg Med Chem. 2016 Aug 15;24(16):3483-93.

Dalmelitinib

生物&药学活性

物理化学性质&存储条件

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Dalmelitinib

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物理化学性质&存储条件

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