PLB-1001 |CAS:1440964-89-5 Probechem Biochemicals

Chemical Structure : PLB-1001

CAS No.: 1440964-89-5

加入收藏

PLB-1001 (Bozitinib, Vebreltinib, PLB1001, CBI-3103, CBT-101)

货号: PC-35732Not For Human Use, Lab Use Only.

PLB-1001 (Bozitinib, PLB1001, CBI-3103, CBT-101) is a potent, highly selective, ATP-competitive, BBB-permeable MET kinase inhibitor, potently inhibits MET activity by 95.1% at 2 uM.

规格	价格	库存
1 mg	￥1280	In stock
5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

PLB-1001 (Bozitinib, Vebreltinib, PLB1001, CBI-3103, CBT-101) is a potent, highly selective, ATP-competitive, BBB-permeable MET kinase inhibitor, potently inhibits MET activity by 95.1% at 2 uM.
Similar with crizotinib, PLB-1001 inhibited the phosphorylation of MET and STAT3, indicating a robust inhibitory effect of PLB-1001 on MET and its downstream signaling pathways.
PLB-1001 demonstrates remarkable potency in selectively inhibiting MET-altered tumor cells (METex14) in preclinical models.
PLB-1001 also exhibits clinical potential for precisely treating gliomas.

物理化学性质&存储条件

分子量	424.391
分子式	C20H15F3N8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(1-cyclopropyl-1H-pyrazol-4-yl)-3-(difluoro(6-fluoro-2-methyl-2H-indazol-5-yl)methyl)-[1,2,4]triazolo[4,3-b]pyridazine

参考文献

1. Hu H, et al. Cell. 2018 Oct 12. pii: S0092-8674(18)31250-9.

PLB-1001 (Bozitinib, Vebreltinib, PLB1001, CBI-3103, CBT-101)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

PLB-1001 (Bozitinib, Vebreltinib, PLB1001, CBI-3103, CBT-101)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.