| Cat. No. |
Product Name |
Information |
| PC-49537 |
TEAD inhibitor TM2
pan-TEAD inhibitor
|
TEAD inhibitor TM2 is a potent pan-TEAD auto-palmitoylation inhibitor with IC50 of 156 and 38 nM for TEAD2 palmitoylation and TEAD4 auto-palmitoylation, respectively, disrupts TEAD-YAP association and specifically inhibits YAP transcriptional activities. |
| PC-49416 |
YAP inhibitor JM7
YAP-TEAD inhibitor
|
JM7 is a small-molecule that inhibits TEAD palmitoylation and stability, affects YAP-TEAD interaction and inhibits YAP transcriptional activity and impairs proliferation, colony formation and migration of breast and ovarian cancer cells. |
| PC-49408 |
MYF-03-69
YAP-TEAD inhibitor
|
MYF-03-69 is a selective, covalent, irreversible TEAD inhibitor, binds with TEAD palmitate pocket, disrupts YAP-TEAD association, suppresses TEAD transcriptional activity (IC50=45 nM) and inhibits cell growth of defective Hippo signaling. |
| PC-49407 |
MYF-03-176
YAP-TEAD inhibitor
|
MYF-03-176 is a potent and orally bioavailable MYF-03-69 analog, pan-TEAD inhibitor that disrupts YAP-TEAD association, suppresses TEAD transcriptional activity (IC50=11 nM). |
| PC-47086 |
MSC-4106
TEAD inhibitor
|
MSC-4106 is a potent, in vivo active inhibitor of TEAD transcription factor with IC50 of 4 and 14 nM in SK-HEP1 reporter and NCI-H226 viability assays, respectively. |
| PC-73283 |
DC-TEAD3in03
TEAD3 inhibitor
|
DC-TEAD3in03 is a potent, selective, covalent TEAD3 inhibitor with IC50 of 0.16 uM, 100-fold selectivity over other TEAD isoforms (IC50>20 uM) in ABPP assays. |
| PC-73282 |
DC-TEADin1072
TEAD1/3 inhibitor
|
DC-TEADin1072 is a novel TEAD1/3 covalent inhibitor with biochemical IC50 values of 0.61 and 0.58 uM against TEAD1 and TEAD3, respectively. |
| PC-73155 |
MYF-01-37
TEAD covalent inhibitor
|
MYF-01-37 (MYF-1-37) is a novel covalent TEAD inhibitor targeting Cys380, binds to palmitoylation pocket in TEAD1, targets YAP dependency upon combined EGFR/MEK inhibition. |
| PC-72508 |
VT104
pan-TEAD inhibitor
|
VT104 (VT-104) is a specific small molecule inhibitor of YAP/TAZ-TEAD-dependent transcription with IC50 of 10.4 nM in YAP reporter assay, pan-TEAD palmitoylation inhibitor. |
| PC-72507 |
VT107
pan-TEAD inhibitor
|
VT107 (VT-107) is a specific small molecule inhibitor of YAP/TAZ-TEAD-dependent transcription with IC50 of 4.93 nM in YAP reporter assay, pan-TEAD palmitoylation inhibitor. |
| PC-72506 |
VT103
TEAD1 inhibitor
|
VT103 (VT-103) is a specific small molecule inhibitor of YAP/TAZ-TEAD-dependent transcription with IC50 of 1.2 nM in YAP reporter assay, selectively blocks TEAD1 auto-palmitoylation. |
| PC-72427 |
LM98
YAP-TEAD inhibitor
|
LM98 (TEAD inhibitor LM98) is a flufenamic acid analogue, shows strong affinity to TEAD, inhibits its autopalmitoylation and reduces the YAP-TEAD transcriptional activity. |
