MYF-03-69

Chemical Structure : MYF-03-69

CAS No.: 2416418-11-4

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货号: PC-49408Not For Human Use, Lab Use Only.

MYF-03-69 is a selective, covalent, irreversible TEAD inhibitor, binds with TEAD palmitate pocket, disrupts YAP-TEAD association, suppresses TEAD transcriptional activity (IC50=45 nM) and inhibits cell growth of defective Hippo signaling.

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10 mg	￥3580	In stock
25 mg	￥5580	In stock
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生物&药学活性

MYF-03-69 is a selective, covalent, irreversible TEAD inhibitor, binds with TEAD palmitate pocket, disrupts YAP-TEAD association, suppresses TEAD transcriptional activity (IC50=45 nM) and inhibits cell growth of defective Hippo signaling.
MYF-03-69 is a pan-TEAD inhibitor, potently inhibits palmitoylation with similar IC50 values at submicromolar concentrations.
MYF-03-69 inhibits TEAD palmitoylation and disrupts endogenous YAP-TEAD association in cells.
MYF-03-69 inhibits TEAD transcription and downregulates YAP target genes expression in mesothelioma cells.
MYF-03-69 selectively inhibits proliferation of cancer cells with YAP or TEAD dependency regardless of lineage.

物理化学性质&存储条件

分子量	443.430
分子式	C22H20F3N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((3R,4R)-3-(4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)-4-((4-(trifluoromethyl)benzyl)oxy)pyrrolidin-1-yl)prop-2-en-1-one

参考文献

1. Mengyang Fan, et al. Elife. 2022 Oct 27;11:e78810.

MYF-03-69

生物&药学活性

物理化学性质&存储条件

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MYF-03-69

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物理化学性质&存储条件

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