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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-YAP-TEAD-TEAD inhibitor 6
TEAD inhibitor 6

Chemical Structure : TEAD inhibitor 6

CAS No.: 2714432-83-2

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TEAD inhibitor 6

货号: PC-20405Not For Human Use, Lab Use Only.

TEAD inhibitor 6 is a highly potent TEAD inhibitor, disrupts the YAP-TEAD interaction with IC50 of 2.7 nM, binds the main interaction site of YAP at the surface of TEAD.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TEAD inhibitor 6 is a highly potent TEAD inhibitor, disrupts the YAP-TEAD interaction with IC50 of 2.7 nM, binds the main interaction site of YAP at the surface of TEAD.

    物理化学性质&存储条件

    分子量 470.93
    分子式 C25H24ClFN2O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((2S)-2-(aminomethyl)-5-chloro-2-phenyl-2,3-dihydrobenzofuran-4-yl)-3-fluoro-4-(2-methoxyethoxy)benzamide

    参考文献

    1. Pascal Furet, et al. ChemMedChem. 2022 Oct 6;17(19):e202200303.

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