MGH-CP1 (MGH-CP-1) | TEAD2/4 inhibitor | Probechem Biochemicals

Chemical Structure : MGH-CP1

CAS No.: 896657-58-2

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MGH-CP1 (MGH-CP-1, TEAD2/4 inhibitor)

货号: PC-49541Not For Human Use, Lab Use Only.

MGH-CP1 (MGH-CP-1) is a specific small molecule TEAD palmitoylation inhibitor, exhibits dose-dependent and potent inhibition of TEAD2/4 auto-palmitoylation in vitro with IC50 of 710 nM and 672 nM, respectively.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
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生物&药学活性

MGH-CP1 (MGH-CP-1) is a specific small molecule TEAD palmitoylation inhibitor, exhibits dose-dependent and potent inhibition of TEAD2/4 auto-palmitoylation in vitro with IC50 of 710 nM and 672 nM, respectively.
MGH-CP1 treatment markedly decreased the palmitoylation levels of endogenous or ectopically expressed TEAD proteins in cells.
MGH-CP1 does not affect auto-palmitoylation of several ZDHHC-family palmitoyl acyltransferases.
MGH-CP1 selectively blocks YAP/TAZ-TEAD downstream transcription in vitro.
MGH-CP1 potently inhibited crypt over-proliferation in Lats1/2 KO intestine, suppresses Myc expression, inhibits over-proliferation, and induces apoptosis in APC-mutated intestine.

物理化学性质&存储条件

分子量	368.50
分子式	C20H24N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1H-1,2,4-Triazol-5-ylthio)-N-(4-tricyclo[3.3.1.13,7]dec-1-ylphenyl)acetamide

参考文献

1. Li Q, et al. Cell Stem Cell. 2020;26:675–692 e678.

2. Sun Y, et al. Nat Commun. 2022 Nov 8;13(1):6744.

MGH-CP1 (MGH-CP-1, TEAD2/4 inhibitor)

生物&药学活性

物理化学性质&存储条件

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MGH-CP1 (MGH-CP-1, TEAD2/4 inhibitor)

生物&药学活性

物理化学性质&存储条件

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