IK-930 | TEAD inhibitor | Probechem Biochemicals

Chemical Structure : IK-930

CAS No.: 2563892-44-2

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IK-930 (IK930, IK 930)

货号: PC-20406Not For Human Use, Lab Use Only.

IK-930 (IK930) is a selective, oral TEAD inhibitor that selectively inhibits TEAD-dependent transcription by directly blocking autopalmitoylation.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

IK-930 (IK930) is a selective, oral TEAD inhibitor that selectively inhibits TEAD-dependent transcription by directly blocking autopalmitoylation.
IK-930 is inactive in a broad panel of kinases, receptors, and transporters, furthering evidence of selectivity.
IK-930 inhibits in vitro proliferation of Hippo pathway-deficient cancer cell lines, but not Hippo pathway wild type cells.
IK-930 demonstrates antitumor activity in mouse xenograft models with Hippo pathway genetic alterations.
IK-930 enhances apoptosis and in vivo antitumor activity in combination with EGFR and MEK inhibitors, respectively, in EGFR or KRAS mutated tumors.

物理化学性质&存储条件

分子量	424.44
分子式	C19H19F3N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzenesulfonamide, N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[[4-(trifluoromethyl)phenyl]methyl]amino]-

参考文献

1. Benjamin S. Amidon, et al. Cancer Res (2022) 82 (12_Supplement): 2156.

IK-930 (IK930, IK 930)

生物&药学活性

物理化学性质&存储条件

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IK-930 (IK930, IK 930)

生物&药学活性

物理化学性质&存储条件

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