YAP inhibitor JM7

Chemical Structure : YAP inhibitor JM7

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货号: PC-49416Not For Human Use, Lab Use Only.

JM7 is a small-molecule that inhibits TEAD palmitoylation and stability, affects YAP-TEAD interaction and inhibits YAP transcriptional activity and impairs proliferation, colony formation and migration of breast and ovarian cancer cells.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

JM7 is a small-molecule that inhibits TEAD palmitoylation and stability, affects YAP-TEAD interaction and inhibits YAP transcriptional activity and impairs proliferation, colony formation and migration of breast and ovarian cancer cells.
JM7 inhibits YAP transcriptional activity in a dose-dependent manner in cellular reportor assays, also inhibits YAP target gene expression, significantly downregulates the expression of both CTGF and CYR61 transcript levels in MDA-MB- 231 and OVCAR-8 cells.
JM7 interferes with YAP/TAZTEAD interaction, directly engages TEAD1-4 in cells.
JM7 (2 uM) inhibits proliferation, colony forming ability and migration of the MDA-MB-231 and OVCAR-8 cancer cells.

物理化学性质&存储条件

分子量	396.399
分子式	C21H20N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	benzo[d][1,3]dioxol-5-ylmethyl (S)-4-(4-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

参考文献

1. Gridnev A, et al. Front Oncol. 2022 Nov 29;12:1021823.