| Cat. No. |
Product Name |
Information |
| PC-20336 |
R428
Axl inhibitor
|
R428 (Bemcentinib, BGB324) is potent, selective and orally bioavailable inhibitor of Axl kinase with IC50 of 14 nM. |
| PC-20335 |
UNC2881
Mer inhibitor
|
UNC2881 (UNC-2881) is a potent selective Mer kinase inhibitor with IC50 of 4.3 nM, 84-fold selectivity over Axl and 58-fold over Tyro3. |
| PC-20334 |
NPS-1034
MET-AXL inhibitor
|
NPS-1034 (NPS1034) is a potent, dual MET and AXL inhibitor with IC50 of 48 and 10.3 nM, respectively. |
| PC-20023 |
Adrixetinib
Axl/Mer inhibitor
|
Adrixetinib is a small molecule inhibitor of Axl/Mer RTK. |
| PC-49565 |
R992
Mer inhibitor
|
R992 (MERTK inhibitor) is a novel potent, selective and orally bioavailable inhibitor of Mer tyrosine kinase (MerTK) with IC50 of 18 nM in ADP-Glo assays. |
| PC-49059 |
MRX-2843
Mer inhibitor
|
MRX-2843 (UNC2371) is a potent, selective, orally available ATP-competitive type 1 inhibitor of both Mer and Flt3 with IC50 of 1.3 and 1.0 nM, respectively. |
| PC-73130 |
ONO-7475
Axl inhibitor
|
ONO-7475 (Tamnorzatinib) is a potent inhibitor of the TAM receptor tyrosine kinase family (Axl IC50=0.7 nM), inhibits the phosphorylation of AXL and Mer, suppresses the growth of AML with FLT3 mutations. |
| PC-72649 |
UNC5293
MER inhibitor
|
UNC5293 (UNC-5293) is a potent, highly selective, orally available inhibitor of MER receptor tyrosine kinase (MERTK) with IC50 0.9 nM, Ki 0.19 nM. |
| PC-72618 |
PF-07265807
Axl/Mer inhibitor
|
PF-07265807 (PF 07265807) is a potent, selective dual Axl/Mer inhibitor with IC50 of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively. |
| PC-72617 |
AZ14145845
Axl/Mer inhibitor
|
AZ14145845 (Dual Axl-Mer inhibitor 32) is a potent, selective dual Axl/Mer inhibitor with pIC50 of 7.0/7.8. |
| PC-72446 |
KRCT-6j
TYRO3 inhibitor
|
KRCT-6j is a potent and selective TYRO3 inhibitor, 300-fold selectivity for TYRO3 over both AXL and MerTK. |
| PC-72371 |
UNC2250
Mer inhibitor
|
UNC2250 is a potent, selective Mer tyrosine kinase (MerTK) inhibitor with IC50 of 1.7 nM, displays >100-fold selectivity over Axland Tyro3. |
