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首页-小分子抑制剂&激动剂-Tyrosine Kinase-TAM Receptor (Tyro3-Axl-Mer)-UNC2881
UNC2881

Chemical Structure : UNC2881

CAS No.: 1493764-08-1

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UNC2881 (UNC 2881)

货号: PC-20335Not For Human Use, Lab Use Only.

UNC2881 (UNC-2881) is a potent selective Mer kinase inhibitor with IC50 of 4.3 nM, 84-fold selectivity over Axl and 58-fold over Tyro3.

规格 价格 库存 数量
10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg ￥4280 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

UNC2881 (UNC-2881) is a potent selective Mer kinase inhibitor with IC50 of 4.3 nM, 84-fold selectivity over Axl and 58-fold over Tyro3.
UNC2881 inhibits endogenous Mer tyrosine kinase activation in acute lymphoblastic leukemia cells with IC50 of 22 nM.
UNC2881 inhibits ligand-stimulated activation of a chimeric protein consisting of the extracellular domain from EGFR and the intracellular domain of Mer.
UNC2881 (3 uM) inhibits collagen-stimulated platelet aggregation in human platelet-rich plasma.

物理化学性质&存储条件

分子量 463.59
分子式 C25H33N7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide

参考文献

1. Weihe Zhang, et al. J Med Chem. 2013 Dec 12;56(23):9693-700.

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