NPS-1034 | MET-AXL inhibitor | Probechem Biochemicals

Chemical Structure : NPS-1034

CAS No.: 1221713-92-3

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NPS-1034 (NPS1034)

货号: PC-20334Not For Human Use, Lab Use Only.

NPS-1034 (NPS1034) is a potent, dual MET and AXL inhibitor with IC50 of 48 and 10.3 nM, respectively.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
50 mg	￥2980	In stock
100 mg	￥4580	In stock
250 mg		Get quote

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生物&药学活性

NPS-1034 (NPS1034) is a potent, dual MET and AXL inhibitor with IC50 of 48 and 10.3 nM, respectively.
NPS-1034 also inhibits other kinases, such as FLT3, KIT, and DDR1.
Combined treatment with NPS-1034 and gefitinib overcomes the drug resistance caused by MET gene amplification.
Addition of NPS-1034 to gefitinib overcomes acquired resistance to gefitinib in a xenograft model.
Addition of NPS-1034 to erlotinib overcomes AXL-mediated drug resistance.
NPS-1034 treatment enhances sensitivity to EGFR-TKIs in H820 cells.
NPS-1034 inhibits ROS1 activity and cell proliferation in HCC78 cells.

物理化学性质&存储条件

分子量	551.55
分子式	C31H23F2N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-1H-pyrazole-4-carboxamide

参考文献

1. Rho JK, et al. Cancer Res. 2014 Jan 1;74(1):253-62.

2. Shin JS, et al. Invest New Drugs. 2014 Jun;32(3):389-99.

NPS-1034 (NPS1034)

生物&药学活性

物理化学性质&存储条件

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NPS-1034 (NPS1034)

生物&药学活性

物理化学性质&存储条件

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