UNC3810A | TYRO3 inhibitor | Probechem Biochemicals

Chemical Structure : UNC3810A

加入收藏

UNC3810A (UNC-3810A, UNC3810)

货号: PC-24219Not For Human Use, Lab Use Only.

UNC3810A (UNC3810) is a potent, selective Tyro3 kinase inhibitor of IC50 of 1.2 nM, >10-fold selectivity versus all other kinases beyond MerTK, the most closely related TAM member, and TRKA.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

UNC3810A (UNC3810) is a potent, selective Tyro3 kinase inhibitor of IC50 of 1.2 nM, >10-fold selectivity versus all other kinases beyond MerTK, the most closely related TAM member, and TRKA.
UNC3810A induces dose-dependent decrease of Tyro3 phosphorylation and attenuates signaling through the PI3K/AKT/mTOR pathway as evidenced by decreased phosphorylation of p85 PI3K and AKT in both HT-29 and B16-F10 cells.
UNC3810A (0.5-1 uM) resulted in a significant attenuation in the formation of colonies for the primary effusion lymphoma (PEL) lines, but not in other NHL subtypes where Tyro3 was not highly expressed.
UNC3810A (25 mg/kg, 3 times a week, i.p.) retards PEL tumor growth in NOD-SCID mice in a BCBL1-PEL xenograft model.

物理化学性质&存储条件

分子量	504.72
分子式	C30H44N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclohexanol, 4-[2-[(2-ethylbutyl)amino]-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, trans-

参考文献

1. Wong JP, et al. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16541-16550.

UNC3810A (UNC-3810A, UNC3810)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

UNC3810A (UNC-3810A, UNC3810)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.