UNC9426 | TYRO3 inhibitor | Probechem Biochemicals

Chemical Structure : UNC9426

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UNC9426 (UNC 9426, UNC-9426)

货号: PC-24218Not For Human Use, Lab Use Only.

UNC9426 is a potent, specific TYRO3 inhibitor with IC50 of 2.1 nM, has 276- and 90-fold selectivity over MERTK and AXL respectively.

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生物&药学活性

UNC9426 is a potent, specific TYRO3 inhibitor with IC50 of 2.1 nM, has 276- and 90-fold selectivity over MERTK and AXL respectively.
UNC9426 is highly selective and TYRO3 is the only kinase that was completely inhibited at 1 uM agianst a 77-kinase panel.
UNC9426 binds tightly to TYRO3 with an EC50 of 89.8 nM in NanoBRET assays, no obvious binding to MERTK or AXL (EC50>10 uM).
UNC9426 inhibits human platelet aggregation, reduces the expression of human platelet surface activation markers, without increasing bleeding time and blocked TYRO3-dependent functions in tumor cells and macrophages.

物理化学性质&存储条件

分子量	632.66
分子式	C32H34F6N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	trans-4-(2-((3,5-Bis(trifluoromethyl)phenyl)amino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexan-1-ol

参考文献

1. Kong D, et al. J Med Chem. 2025 Mar 11. doi: 10.1021/acs.jmedchem.5c00048.

UNC9426 (UNC 9426, UNC-9426)

生物&药学活性

物理化学性质&存储条件

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UNC9426 (UNC 9426, UNC-9426)

生物&药学活性

物理化学性质&存储条件

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