| Cat. No. |
Product Name |
Information |
| PC-27593 |
TLX agonist 4
TLX agonist
|
TLX agonist 4 (Compound 35) is highly potent and selective activator of transcription factor tailless (TLX, NR2E1) with pEC50 of 8.0. |
| PC-27592 |
TLX agonist 2
TLX agonist
|
TLX agonist 2 (Compound 31) is a small molecule agonist of orphan nuclear receptor tailless (TLX, NR2E1) with EC50 of 0.1 uM and Kd of 0.16 uM, potentiates TLX transcriptional repressive activity. |
| PC-27591 |
TLX agonist 1
TLX agonist
|
TLX agonist 1 (Compound ccrp2) is a specific small molecule agonist of orphan nuclear receptor tailless (TLX, NR2E1), specifically binds to TLX LBD with Kd of 650 nM, potentiates TLX transcriptional repressive activity. |
| PC-24566 |
Ellorarxine
RAR modulator
|
Ellorarxine (DC645, NVG0645) is a synthetic retinoic acid and mimic of all-trans-retinoic acid, and a potent, CNS-permeable RAR modulator. |
| PC-24565 |
HNF4 agonist 46
HNF4 agonist
|
HNF4 agonist 46 is a first-in-class, high-affinity hepatocyte nuclear factor 4 (HNF4) agonist, activates HNF4α (EC50=6 nM) and HNF4γ (EC50=17 nM) with low nanomolar potency, binds to HNF4α LBD with ITC Kd of 23 nM. |
| PC-23768 |
YCT-529
RARα antagonist
|
YCT-529 (YCT529) is a potent and selective RARα antagonist with IC50 of 6.8 nM, shows no activity against RARβ and RARγ up to 30 uM. |
| PC-23692 |
IRX5010
RARγ agonist
|
IRX5010 (IRX4647F) is a second generation, potent, highly selective RARγ agonist with EC50 of <0.1 nM in RARγ transactivation reporter assays, >1000-fold selective over RARα. |
| PC-23686 |
LG100754
RXR homodimer antagonist
|
LG100754 (UVI 2112) is a specific antagonist of RXR homodimer also functions as a RXR:PPARα and RXR:PPARγ agonist. |
| PC-21838 |
KCL-286
RARβ agonist
|
KCL-286 (C286) is a potent, selective and orally bioavailable RARβ agonist with EC50 of 1.9 nM/26 nM/13 nM for RARβ/RARα/RARγ, respectively. |
| PC-21836 |
CD666
RARγ agonist
|
CD666 is a potent, selective RARgamma (RARγ) agonist. |
| PC-21835 |
CD2665
RARγ inhibitor
|
CD2665 is a potent, selective and orally active RAR-β/ RAR-γ antagonist with Ki of 306 and 110 nM, respectively. |
| PC-21210 |
BMS961
RARgamma agonist
|
BMS961 (BMS-189961) is a potent, selective retinoic acid receptor-gamma (RARγ) agonist. |
