IRX5010 | RARγ agonist | Probechem Biochemicals

Chemical Structure : IRX5010

CAS No.: 856683-59-5

加入收藏

IRX5010 (IRX4647F)

货号: PC-23692Not For Human Use, Lab Use Only.

IRX5010 (IRX4647F) is a second generation, potent, highly selective RARγ agonist with EC50 of <0.1 nM in RARγ transactivation reporter assays, >1000-fold selective over RARα.

规格	价格	库存
5 mg	￥3880	In stock
10 mg	￥5880	In stock
25 mg	￥8980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

IRX5010 (IRX4647F) is a second generation, potent, highly selective RARγ agonist with EC50 of <0.1 nM in RARγ transactivation reporter assays, >1000-fold selective over RARα.
IRX5010 demonstrates no significant inhibitory activity in vitro on EMT-6 proliferation at concentrations lower than 20-100 uM.
IRX5010 demonstrates substantial dose dependent treatment effects relative to vehicle control (59-73%) on inhibition of growth of EMT-6 syngeneic murine triple negative breast cancer in vivo.
IRX5010 induces tumor infiltrating T-lymphocytes of effector memory phenotypes, demonstrating immunity promoting effects in the tumor immune microenvironment.

物理化学性质&存储条件

分子量	395.47
分子式	C24H26FNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-fluoro-4-((1E,3E)-3-(hydroxyimino)-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl)benzoic acid

参考文献

1. Martin Sanders, et al. Cancer Res (2024) 84 (9_Supplement): PO5-24-12.

IRX5010 (IRX4647F)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

IRX5010 (IRX4647F)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.