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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-RAR/RXR-LG100754
LG100754

Chemical Structure : LG100754

CAS No.: 180713-37-5

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LG100754 (LG-100754, UVI 2112)

货号: PC-23686Not For Human Use, Lab Use Only.

LG100754 (UVI 2112) is a specific antagonist of RXR homodimer also functions as a RXR:PPARα and RXR:PPARγ agonist.

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5 mg ￥2880 In stock
10 mg ￥4580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LG100754 (UVI 2112) is a specific antagonist of RXR homodimer, also functions as a RXR:PPARα and RXR:PPARγ agonist.
LG100754 does not activate other heterodimers like RXR:liver X receptoralpha, RXR:liver X receptorbeta, RXR:bile acid receptor/farnesoid X receptor and RXR:nerve growth factor induced gene B.
LG100754 triggers cellular RXR:PPARgamma-dependent pathways including adipocyte differentiation and inhibition of TNFalpha-mediated hypophosphorylation of the insulin receptor, but does not activate key farnesoid X receptor and liver X receptor target genes.
LG100754 treatment of db/db animals leads to an improvement in insulin resistance in vivo.
LG100754 sensitizes the potency of proliferator-activated receptor (PPAR) gamma-retinoid X receptor heterodimers for PPARgamma ligands.

物理化学性质&存储条件

分子量 396.57
分子式 C26H36O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2E,4E,6Z)-3-Methyl-7-(5,5,8,8-tetramethyl-3-propoxy-5,6,7,8-tetrahydronaphthalen-2-yl)octa-2,4,6-trienoic acid

参考文献

1. Lala DS, et al. Nature. 1996 Oct 3;383(6599):450-3.

2. Cesario RM, et al. Mol Endocrinol. 2001 Aug;15(8):1360-9.

3. Forman BM. J Biol Chem. 2002 Apr 12;277(15):12503-6.

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