KCL-286 (C286) | RARβ agonist | Probechem Biochemicals

Chemical Structure : KCL-286

CAS No.: 1952276-71-9

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KCL-286 (C286, KCL286)

货号: PC-21838Not For Human Use, Lab Use Only.

KCL-286 (C286) is a potent, selective and orally bioavailable RARβ agonist with EC50 of 1.9 nM/26 nM/13 nM for RARβ/RARα/RARγ, respectively.

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5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5480	In stock
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100 mg		Get quote

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生物&药学活性

KCL-286 (C286) is a potent, selective and orally bioavailable RARβ agonist with EC50 of 1.9 nM/26 nM/13 nM for RARβ/RARα/RARγ, respectively.
KCL-286 (C286) displays 5-23 fold selectivity for RARβ over RARα (23 fold) and for RARβ over RARγ (5 fold) against the human RAR ligand-binding domains.
KCL-286 (C286) possess a promising pharmacokinetic profile in both rat and dog.
KCL-286 (C286) increases neurite outgrowth in vitro and induce sensory axon regrowth in vivo in a rodent model of avulsion and crush injury.

物理化学性质&存储条件

分子量	334.33
分子式	C19H14N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(5-(4,7-dimethylbenzofuran-2-yl)-1,2,4-oxadiazol-3-yl)benzoic acid

参考文献

1. Maria B Goncalves, et al. Bioorg Med Chem Lett. 2019 Apr 15;29(8):995-1000.

2. Maria B Goncalves, et al. Br J Clin Pharmacol. 2023 Dec;89(12):3573-3583.

KCL-286 (C286, KCL286)

生物&药学活性

物理化学性质&存储条件

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KCL-286 (C286, KCL286)

生物&药学活性

物理化学性质&存储条件

参考文献

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