| Cat. No. |
Product Name |
Information |
| PC-21605 |
AG-946
Pyruvate Kinase activator
|
AG-946 (Tebapivat, AG946) is a potent, allosteric activator of wild-type and mutant RBC-specific form of pyruvate kinase (PKR) with AC50 of 5 nM for human wild-type PK, 4.3 nM and 6.9 nM for mutated K410E and R510Q PK proteins, resepctively. |
| PC-49688 |
HA344
PKM2/IMPDH inhibitor
|
HA344 (HA 344) is a dual covalent inhibitor of pyruvate kinase M2 (PKM2) and inosine monophosphate dehydrogenase (IMPDH), efficiently inhibits cutaneous metastatic melanoma (CMM). |
| PC-38586 |
ML202
PKM2 activator
|
ML202 (CID-44246498) is a highly specific, allosteric activator for the tumor-specific isoform of human pyruvate kinase M2 (PKM2) with EC50 value of 73 nM, inactive against hPyk-M1, -R, and -L isoforms. |
| PC-38268 |
NPD10084
PKM2 inhibitor
|
NPD10084 (NPD 10084) is a novel compound that targets pyruvate kinase muscle isoform 2 (PKM2), exerts anti-proliferative activity against colorectal cancer cells in vitro (IC50=0.8-1.9 uM) and in vivo. |
| PC-43151 |
Mitapivat
Pyruvate kinase activator
|
Mitapivat (PKM2 activator 1020, AG-348) is a first-in-class, allosteric activator of Pyruvate kinase (PK) with mean AC50 of 29 nM (PK-R), activates a spectrum of recombinant mutant PK-R enzymes (R532W, R510Q). |
| PC-45505 |
TEPP-46
PKM2 activator
|
TEPP-46 (ML265) is a potent activator of PKM2 (pyruvate kinase M2) with IC50 of 92 nM. |
| PC-45611 |
DASA-58
PKM2 activator
|
A potent activator of PKM2 (pyruvate kinase M2) with AC50 of 38 nM. |
| PC-23535 |
Micheliolide
PKM2 activator
|
Micheliolide (MCL) is a potent, selective and allosteric activator of PKM2, selectively activates pyruvate kinase M2 (PKM2) through the covalent binding at Cys424, effectively promotes the pyruvate kinase activity of rPKM2 with AC50 of 6 nM, shows broad-spectrum anticancer and anti-inflammation activity. |
| PC-23534 |
ACT001
NF-κB inhibitor, PKM2 activator
|
ACT001 (dimethylaminomicheliolide, DMAMCL) is a guaianolide sesquiterpene lactone that targets lasminogen activator inhibitor-1 (PAI-1), also is a a nuclear factor-κB (NF-κB) signaling pathway inhibitor and PKM2 activator, effectively inhibits the proliferation of both tamoxifen-sensitive and tamoxifen-resistant cells. |
| PC-23510 |
D34-919
ALDH1A3-PKM2 inhibitor
|
D34-919 is a small-molecule inhibitor that potently disrupts the ALDH1A3-PKM2 interaction, preventing the ALDH1A3-mediated enhancement of PKM2 tetramerization, binds to PKM2. |
| PC-22788 |
Urolithin C
PKL inhibitor
|
Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion, Urolithin C is a L-type Ca2+ channel opener and enhances Ca2+ influx, also is an allosteric inhibitor of liver-specific isoform of pyruvate kinase (PKL). |
| PC-22681 |
PKM2 aggregates inhibitor K27
PKM2 aggregates inhibitor
|
PKM2 aggregates inhibitor K27 is a small molecule capable of dissolving PKM2 aggregates and alleviating senescence, restores PKM2 enzymatic activity and glycolytic flux, delays aging of naturally and prematurely aged mice. |
