NPD10084 | PKM2 inhibitor | Probechem Biochemicals

Chemical Structure : NPD10084

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NPD10084 (NPD 10084)

货号: PC-38268Not For Human Use, Lab Use Only.

NPD10084 (NPD 10084) is a novel compound that targets pyruvate kinase muscle isoform 2 (PKM2), exerts anti-proliferative activity against colorectal cancer cells in vitro (IC50=0.8-1.9 uM) and in vivo.

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100 mg		Get quote

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生物&药学活性

NPD10084 (NPD 10084) is a novel compound that targets pyruvate kinase muscle isoform 2 (PKM2), exerts anti-proliferative activity against colorectal cancer cells in vitro (IC50=0.8-1.9 uM) and in vivo.
NPD10084 interrupted protein-protein interactions between PKM2 and β-catenin or STAT3, with subsequent suppression of downstream signaling, also inhibited the interaction between PKM2 and STAT3.
The anti-proliferative activity of NPD10084 may not be mediated by an alteration in the pyruvate kinase activity of PKM2.
NPD10084 partially suppressed the tumor growth of colorectal cancer cells in HCT116 xenograft mouse model.

物理化学性质&存储条件

分子量	345.402
分子式	C21H19N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-methoxy-1H-indol-2-yl)(1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)methanone

参考文献

1. Ikuko Nagasawa, et al. Cell Chem Biol. 2020 Feb 20;27(2):186-196.e4.

NPD10084 (NPD 10084)

生物&药学活性

物理化学性质&存储条件

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NPD10084 (NPD 10084)

生物&药学活性

物理化学性质&存储条件

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