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首页-小分子抑制剂&激动剂-Others-Pyruvate Kinase-Mitapivat
Mitapivat

Chemical Structure : Mitapivat

CAS No.: 1260075-17-9

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Mitapivat (PKM2 activator 1020, AG-348, AG348)

货号: PC-43151Not For Human Use, Lab Use Only.

Mitapivat (PKM2 activator 1020, AG-348) is a first-in-class, allosteric activator of Pyruvate kinase (PK) with mean AC50 of 29 nM (PK-R), activates a spectrum of recombinant mutant PK-R enzymes (R532W, R510Q).

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10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2480 In stock
100 mg ￥3980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Mitapivat (PKM2 activator 1020, AG-348) is a first-in-class, allosteric activator of Pyruvate kinase (PK) with mean AC50 of 29 nM (PK-R), activates a spectrum of recombinant mutant PK-R enzymes (R532W, R510Q).
AG-348 can increase the activity of wild-type and mutant PK enzymes in biochemical assays and in patient red blood cells treated ex vivo.
AG-348 demonstrates enhanced glycolytic pathway activity in PK-deficient RBCs that contain a variety of mutations.

物理化学性质&存储条件

分子量 450.5533
分子式 C24H26N4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-Quinolinesulfonamide, N-[4-[[4-(cyclopropylmethyl)-1-piperazinyl]carbonyl]phenyl]-

参考文献

1. Qi W, et al. Nat Med. 2017 Jun;23(6):753-762.

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