ML202 | PKM2 activator | Probechem Biochemicals

Chemical Structure : ML202

CAS No.: 1221186-52-2

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ML202 (ML 202, CID-44246498)

货号: PC-38586Not For Human Use, Lab Use Only.

ML202 (CID-44246498) is a highly specific, allosteric activator for the tumor-specific isoform of human pyruvate kinase M2 (PKM2) with EC50 value of 73 nM, inactive against hPyk-M1, -R, and -L isoforms.

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5 mg	￥2180	In stock
10 mg	￥3480	In stock
25 mg	￥5580	In stock
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100 mg		Get quote

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生物&药学活性

ML202 (CID-44246498) is a highly specific, allosteric activator for the tumor-specific isoform of human pyruvate kinase M2 (PKM2) with EC50 value of 73 nM, inactive against hPyk-M1, -R, and -L isoforms.
ML202 affects the cooperativity of phosphoenolpyruvate (PEP) binding to PKM2, with little affect on adenosine diphosphate (ADP) binding, in a manner similar to Fructose-1,6-bisphosphate (FBP).

物理化学性质&存储条件

分子量	387.472
分子式	C18H17N3O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,6-Dihydro-6-[(3-methoxyphenyl)methyl]-4-methyl-2-(methylsulfinyl)-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one

参考文献

1. Matthew B Boxer, et al. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.

ML202 (ML 202, CID-44246498)

生物&药学活性

物理化学性质&存储条件

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ML202 (ML 202, CID-44246498)

生物&药学活性

物理化学性质&存储条件

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