Etavopivat | PKR activator | Probechem Biochemicals

Chemical Structure : Etavopivat

CAS No.: 2245053-57-8

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Etavopivat (FT-4202)

货号: PC-72959Not For Human Use, Lab Use Only.

Etavopivat (FT-4202) is a novel oral activator of PKR that decreases 2,3-DPG levels and hence would increase the HbS O2 affinity to reduce sickling.

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5 mg	￥6880	In stock
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生物&药学活性

Etavopivat (FT-4202) is a novel oral activator of PKR that decreases 2,3-DPG levels and hence would increase the HbS O2 affinity to reduce sickling.
FT-4202 increases the hemoglobin S O2 affinity to reduce sickling and improve RBC membrane deformability.
Etavopivat (FT-4202) increased Hb-oxygen affinity and reduced sickling under deoxygenation in ex vivo RBCs from donors with sickle cell disease (SCD).
Oral administration of FT-4202 increases Hb and improves RBC parameters in BERK mice.
Etavopivat is currently being evaluated in clinical trials for the treatment sickle cell disease (SCD).

物理化学性质&存储条件

分子量	457.501
分子式	C22H23N3O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-1-(5-(2,3-Dihydro(1,4)dioxino(2,3-b)pyridine-7- sulfonyl)-3,4,5,6-tetrahydropyrrolo(3,4-C)pyrrol-2(1H)- YL)-3-hydroxy-2-phenylpropan-1-one

参考文献

1. Shrestha A, et al. Blood Adv. 2021 May 11;5(9):2385-2390.

2. Forsyth S, et al. Clin Pharmacol Drug Dev. 2022 Jan 12.

3. Schroeder P, et al. J Pharmacol Exp Ther. 2022 Mar;380(3):210-219.

Etavopivat (FT-4202)

生物&药学活性

物理化学性质&存储条件

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Etavopivat (FT-4202)

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