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首页-小分子抑制剂&激动剂-Others-Pyruvate Kinase-TEPP-46
TEPP-46

Chemical Structure : TEPP-46

CAS No.: 1221186-53-3

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TEPP-46 (ML265, TEPP46, ML-265)

货号: PC-45505Not For Human Use, Lab Use Only.

TEPP-46 (ML265) is a potent activator of PKM2 (pyruvate kinase M2) with IC50 of 92 nM.

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10 mg ￥1180 In stock
25 mg ￥1880 In stock
50 mg ￥2680 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TEPP-46 (ML265) is a potent activator of PKM2 (pyruvate kinase M2) with IC50 of 92 nM.
TEPP-46 shows no activity on PKM1 in vitro.
TEPP-46 binds to PKM2 at the subunit interaction interface site that is distinct from that of the endogenous activator FBP.
TEPP-46 inhibits xenograft tumor growth and orally bioactive.

物理化学性质&存储条件

分子量 372.4645
分子式 C17H16N4O2S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 28 mg/mL
Chemical Name/SMILES

5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one, 6-[(3-aminophenyl)methyl]-4,6-dihydro-4-methyl-2-(methylsulfinyl)-

参考文献

1. Anastasiou D, et al. Nat Chem Biol. 2012 Oct;8(10):839-47.

2. Qi W, et al. Nat Med. 2017 Apr 24. doi: 10.1038/nm.4328.

3. Witney TH, et al. Sci Transl Med. 2015 Oct 21;7(310):310ra169.

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