| Cat. No. |
Product Name |
Information |
| PC-42596 |
Ixazomib
Proteasome inhibitor
|
Ixazomib (MLN2238) is a potent, selective, orally bioavailable proteasome inhibitor with IC50 of 3.4 nM. |
| PC-42595 |
MLN9708
Proteasome inhibitor
|
Ixazomib citrate (MLN9708) is a potent, selective, orally bioavailable proteasome inhibitor with IC50 of 3.4 nM. |
| PC-42470 |
Bortezomib
Proteasome inhibitor
|
Bortezomib (PS341) is a potent, selective, competitive, orally active Proteasome inhibitor with Ki of 0.6 nM for 20S Proteasome. |
| PC-42597 |
Delanzomib
Proteasome inhibitor
|
Delanzomib (CEP18770) is a potent, orally active proteasome inhibitor with IC50 of 3.8 nM against chymotrypsin-like proteasome activity. |
| PC-42598 |
Carfilzomib
Proteasome inhibitor
|
Carfilzomib (PR-171) is a potent, highly selective inhibitor chymotrypsin-like activity of proteasome with IC50 of 6 nM. |
| PC-45547 |
VR23
Proteasome inhibitor, HES1 inhibitor
|
VR23 is a potent inhibitor of trypsin-like proteasome (IC50=1 nM), chymotrypsin-like proteasome (IC50=50-100 nM) and caspase-like proteasome (IC50=3 uM). |
| PC-42242 |
RA190
Rpn13 inhibitor
|
RA190 (RA-190) is a reversible, highly selective, orally active inhibitor of the proteasomal ubiquitin receptor Rpn13, exhibits potent anti-proliferative effects against MM lines (IC50<0.1 uM) and HPV-transformed cells (IC50<0.3 uM). |
| PC-28687 |
Zetomipzomib maleate
LMP7/LMP2 inhibitor
|
Zetomipzomib maleate (KZR-616) is a first-in-class inhibitor of immunoproteasome, dually inhibits immunoproteasome subunits LMP7 (IC50, 39/57 nM, hLMP7/mLMP7) and LMP2 (IC50, 131/179 nM, hLMP2/mLMP2). |
| PC-28483 |
CSN5-14
CSN5 inhibitor
|
CSN5-14 is a small molecule COP9 signalosome subunit 5 (CSN5, JAB1) inhibitor with IC50 of 0.73 uM, inhibits TNBC cell proliferation and clonogenic survival. |
| PC-27935 |
Atractylenolide I
PSMD4 modulator, Tumor antigen presentation activator
|
Atractylenolide I (ATT-I, AT-I) is a sesquiterpene derived from the rhizome of Atractylodes macrocephala within neuroprotective, anti-allergic, anti-inflammatory and anticancer properties, targets and binds proteasome 26S subunit non-ATPase 4 (PSMD4) with MST KD of 0.4 uM, enhances antigen presentation on tumor cells. |
| PC-27246 |
YU102
LMP2/Y inhibitor
|
YU102 is a potent, selective dual inhibitor of immunoproteasome (iP) catalytic subunit LMP2 and constitutive proteasome (cP) catalytic subunit Y with IC50 of 105.2 nM (LMP2/β1i) and 206.7 nM (Y/β1), shows no activity against X/β5 and LMP7/β5i. |
| PC-25747 |
PKS3053
β5i inhibitor
|
PKS3053 is a potent, selective inhibitor of immunoproteasome (i-20S) subunit LMP7 (β5i/PSMB8) with IC50 of 0.5 nM, 118-fold selective over constitutive proteasome (c-20S) β5c (PSMB5). |
