Bortezomib | Proteasome inhibitor | Probechem Biochemicals

Chemical Structure : Bortezomib

CAS No.: 179324-69-7

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Bortezomib (PS-341, PS341)

货号: PC-42470Not For Human Use, Lab Use Only.

Bortezomib (PS341) is a potent, selective, competitive, orally active Proteasome inhibitor with Ki of 0.6 nM for 20S Proteasome.

规格	价格	库存
10 mg	￥580	In stock
25 mg	￥980	In stock
50 mg	￥1580	In stock
100 mg	￥2380	In stock
250 mg		Get quote

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生物&药学活性

Bortezomib (PS341) is a potent, selective, competitive, orally active Proteasome inhibitor with Ki of 0.6 nM for 20S Proteasome.
Bortezomib (PS341) shows only modest activity toward serine and thiol proteases (cathepsin G, elastase, chymotrypsin Ki>300 nM).
Bortezomib (PS341) inhibits the TNFα-stimulated activation of NF-κB in primary HUVE cells (IC50=0.5 uM) by blocking the degradation of the inhibitor IκBα.
Bortezomib (PS341) exhibits anti-inflammatory effects in vivo.

物理化学性质&存储条件

分子量	384.2372
分子式	C19H25BN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Boronic acid, B-[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]-

参考文献

1. Palombella VJ, et al. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15671-6.

2. Frankel A, et al. Clin Cancer Res. 2000 Sep;6(9):3719-28.

3. Teicher BA, et al. Clin Cancer Res. 1999 Sep;5(9):2638-45.

4. Adams J, et al. Bioorg Med Chem Lett. 1998 Feb 17;8(4):333-8.

Bortezomib (PS-341, PS341)

生物&药学活性

物理化学性质&存储条件

参考文献

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Bortezomib (PS-341, PS341)

生物&药学活性

物理化学性质&存储条件

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