Carfilzomib | Proteasome inhibitor | Probechem Biochemicals

Chemical Structure : Carfilzomib

CAS No.: 868540-17-4

加入收藏

Carfilzomib (PR171, PR-171)

货号: PC-42598Not For Human Use, Lab Use Only.

Carfilzomib (PR-171) is a potent, highly selective inhibitor chymotrypsin-like activity of proteasome with IC50 of 6 nM.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
100 mg	￥3780	In stock
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Carfilzomib (PR-171) is a potent, highly selective inhibitor chymotrypsin-like activity of proteasome with IC50 of 6 nM.
Carfilzomib (PR-171) weakly inhibits caspase-like and trypsin-like activities in cellular assays (IC50150-200 nM), also inhibits the chymotrypsin-like activity of the immunoproteasome (IC50=33 nM).
Carfilzomib (PR-171) accumulates proteasome substrates and induces cell cycle arrest and/or apoptosis.
Carfilzomib (PR-171) shows antitumor efficacy in vivo.

物理化学性质&存储条件

分子量	719.9099
分子式	C40H57N5O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Phenylalaninamide, (αS)-α-[[2-(4-morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-

参考文献

1. Kuhn DJ, et al. Blood. 2007 Nov 1;110(9):3281-90.

2. Parlati F, et al. Blood. 2009 Oct 15;114(16):3439-47.

3. O'Connor OA, et al. Clin Cancer Res. 2009 Nov 15;15(22):7085-91.

4. Demo SD, et al. Cancer Res. 2007 Jul 1;67(13):6383-91.

Carfilzomib (PR171, PR-171)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Carfilzomib (PR171, PR-171)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.