Delanzomib | Proteasome inhibitor | Probechem Biochemicals

Chemical Structure : Delanzomib

CAS No.: 847499-27-8

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Delanzomib (CEP-18770, CEP18770)

货号: PC-42597Not For Human Use, Lab Use Only.

Delanzomib (CEP18770) is a potent, orally active proteasome inhibitor with IC50 of 3.8 nM against chymotrypsin-like proteasome activity.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

Delanzomib (CEP18770) is a potent, orally active proteasome inhibitor with IC50 of 3.8 nM against chymotrypsin-like proteasome activity.
Delanzomib demonstrates marginal inhibition of the tryptic and peptidyl glutamyl activities of the proteosome.
Delanzomib down-modulates the NF-kappaB activity and the expression of several NF-kappaB downstream effectors, induces apoptotic cell death in MM cells.
Delanzomib demonstrates tumor regression in MM xenografts with favorable tumor selectivity profile.

物理化学性质&存储条件

分子量	413.2751
分子式	C21H28BN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Boronic acid, B-[(1R)-1-[[(2S,3R)-3-hydroxy-1-oxo-2-[[(6-phenyl-2-pyridinyl)carbonyl]amino]butyl]amino]-3-methylbutyl]-

参考文献

1. Piva R, et al. Blood. 2008 Mar 1;111(5):2765-75.

2. Sanchez E, et al. Br J Haematol. 2010 Feb;148(4):569-81.

3. Seavey MM, et al. Int Immunopharmacol. 2012 Jan;12(1):257-70.

4. Berkers CR, et al. Mol Pharm. 2012 May 7;9(5):1126-35.

Delanzomib (CEP-18770, CEP18770)

生物&药学活性

物理化学性质&存储条件

参考文献

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Delanzomib (CEP-18770, CEP18770)

生物&药学活性

物理化学性质&存储条件

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