CSN5-14

Chemical Structure : CSN5-14

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货号: PC-28483Not For Human Use, Lab Use Only.

CSN5-14 is a small molecule COP9 signalosome subunit 5 (CSN5, JAB1) inhibitor with IC50 of 0.73 uM, inhibits TNBC cell proliferation and clonogenic survival.

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生物&药学活性

CSN5-14 is a small molecule COP9 signalosome subunit 5 (CSN5, JAB1) inhibitor with IC50 of 0.73 uM, inhibits TNBC cell proliferation and clonogenic survival.
CSN5-14 effectively engages intracellular CSN5 and suppress its deneddylase activity in a dose- and time-dependent manner.
CSN5-14 induces dose- and time-dependent accumulation of NEDD8-Cul1 in TNBC cells, without altering the protein level of CSN5.
CSN5-14 displays potent cytotoxicity with IC50 values of 8.1 uM in MDA-MB-231 and 5.8 uM in MDA-MB-468 cells.
CSN5-14 significantly impaired clonogenic capacity in a dose-dependent manner in MDA-MB-231 cells.
CSN5-14 elevate ROS, induce cell-cycle arrest and apoptosis in TNBC cells.

物理化学性质&存储条件

分子量	483.62
分子式	C29H33N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((2-(5-methyl-[1,1′-biphenyl]-2-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)amino)propyl)-2-morpholinoacetamide

参考文献

1. Yang Z, et al. Eur J Med Chem. 2026 Oct 9;321(Pt 1):119410.

CSN5-14

生物&药学活性

物理化学性质&存储条件

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CSN5-14

生物&药学活性

物理化学性质&存储条件

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