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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Proteasome-Atractylenolide I
Atractylenolide I

Chemical Structure : Atractylenolide I

CAS No.: 73069-13-3

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Atractylenolide I (ATT-I, AT-I)

货号: PC-27935Not For Human Use, Lab Use Only.

Atractylenolide I (ATT-I, AT-I) is a sesquiterpene derived from the rhizome of Atractylodes macrocephala within neuroprotective, anti-allergic, anti-inflammatory and anticancer properties, targets and binds proteasome 26S subunit non-ATPase 4 (PSMD4) with MST KD of 0.4 uM, enhances antigen presentation on tumor cells.

规格 价格 库存 数量
10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Atractylenolide I (ATT-I, AT-I) is a sesquiterpene derived from the rhizome of Atractylodes macrocephala within neuroprotective, anti-allergic, anti-inflammatory and anticancer properties, targets and binds proteasome 26S subunit non-ATPase 4 (PSMD4) with MST KD of 0.4 uM, enhances antigen presentation on tumor cells.
Atractylenolide I (ATT-I) promotes CD8+ T cell–mediated tumor cell killing.
Atractylenolide I (ATT-I) enhances the antigen-specific T cell responses in MC38 tumor–derived organoids.
Atractylenolide I (ATT-I) promotes the activity of immunoproteasome in a PSMD4-dependent manner, binds to PSMD4 and stabilizes the PSMD4 and PSMD7 interaction, leading to enhanced proteasomal activities.
Atractylenolide I (ATT-I) promotes antigen presentation and enhances the efficacy of CRC immunotherapy.
Atractylenolide I (ATT-I) enhances tumor-infiltrating lymphocytes and antitumor activity of cytotoxic T lymphocytes.

物理化学性质&存储条件

分子量 230.31
分子式 C15H18O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4aS,8aS)-3,8a-Dimethyl-5-methylene-4a,5,6,7,8,8a-hexahydronaphtho[2,3-b]furan-2(4H)-one

参考文献

1. Xu H, et al. J Clin Invest. 2026 May 1;136(9):e208647.

2. Miao Y, et al. iScience. 2026 Aug 21;29(9):117259.

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