RA190 | Rpn13 inhibitor | Probechem Biochemicals

Chemical Structure : RA190

CAS No.: 1617495-03-0

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RA190 (RA-190, RA 190)

货号: PC-42242Not For Human Use, Lab Use Only.

RA190 (RA-190) is a reversible, highly selective, orally active inhibitor of the proteasomal ubiquitin receptor Rpn13, exhibits potent anti-proliferative effects against MM lines (IC50<0.1 uM) and HPV-transformed cells (IC50<0.3 uM).

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

RA190 (RA-190) is a reversible, highly selective, orally active inhibitor of the proteasomal ubiquitin receptor Rpn13, exhibits potent anti-proliferative effects against MM lines (IC50<0.1 uM) and HPV-transformed cells (IC50<0.3 uM).
RA190 is a bis-benzylidine piperidone that covalently binds to Cys 88 of ubiquitin receptor RPN13 in the 19S regulatory particle and inhibits proteasome function.
RA190 inhibits proteasome function, triggering rapid accumulation of polyubiquitinated proteins.
RA190 profoundly reduced growth of MM and ovarian cancer xenografts.

物理化学性质&存储条件

分子量	596.7594
分子式	C28H23Cl5N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 10 mM
Chemical Name/SMILES	4-Piperidinone, 1-[(2S)-2-amino-1-oxo-3-phenylpropyl]-3,5-bis[(3,4-dichlorophenyl)methylene]-, hydrochloride (1:1)

参考文献

1. Anchoori RK, et al. Cancer Cell. 2013 Dec 9;24(6):791-805.

2. Randles L, et al. J Biol Chem. 2016 Apr 15;291(16):8773-83.

3. Song Y, et al. Leukemia. 2016 Sep;30(9):1877-86.

RA190 (RA-190, RA 190)

生物&药学活性

物理化学性质&存储条件

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RA190 (RA-190, RA 190)

生物&药学活性

物理化学性质&存储条件

参考文献

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